An important genetic syndrome characterized by severe motor and intellectual retardation, microcephaly (abnormally small head), ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia (floppiness), hyperactivity, seizures, absence of speech, frequent smiling and outbursts of laughter, and an unusual facies (facial appear [..]

a congenital disorder reflected by an abnormality on chromosome 15. Causes defects in neurology, motor functioning (gait abnormality), cognitive abilities (severe learning disabilities), and the prope [..]

a rare genetically inherited form of mental retardation due to the deletion or inactivation of specific genes on chromosome 15.  The inheritance of this syndrome is subject to genome imprinting.  Children with Angleman syndrome typically also have small heads, experience seizures, have pronounced speech impairment, are hyperactive, and have [..]

A Syndrome characterized by multiple abnormalities, Mental Retardation, and Movement Disorders. Present usually are Skull and other abnormalities, frequent Infantile Spasms (Spasms, Infantile); easily [..]

A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily [..]

<syndrome> A dysmorphic mental retardation syndrome, that has generated considerable interest in human genetics as a prototypic example of genomic imprinting in man. Usually a sporadic disorder, it is characterised by profound intellectual deficiency, a striking puppet-like ataxic gait and facial features, paroxysmal laughter and seizures. Th [..]