a pharmacological agent that is added to a vaccine to enhance the immune response of the vaccine recipient.

 - the process by which B cells produce antibodies with increased affinity for antigen during an immune response.

a protein molecule that is made and secreted by B cells in response to stimulation from antigens, such as viruses. Each antibody specifically binds to one antigen, which they target for neutralization [..]

 - a collaborative project of the Duke CHAVI-ID and the NIH Vaccine Research Center to isolate the evolution pathways of all known specificities of HIV-1 broadly neutralizing antibodies (BnAbs) and th [..]

a foreign substance, such as a virus, that enters the body and induces an immune response. Similar to a lock and key, antigens specifically bind to their respective antibodies via the epitopes that ar [..]

 - B lineage cells that are produced in the bone marrow before maturing into B cells.

 - a vaccine strategy of the Duke CHAVI-ID that is based on targeting the unmutated common ancestor (UCA) and intermediate antibody (IA) of broadly neutralizing antibody lineages using Envs or Env sub [..]

 - the strength of the interaction between a single antigen binding site on an antibody and a single epitope on an antigen.

 - antibodies that are capable of neutralizing a wide range of HIV-1 strains; however, they are rarely made during infection and are difficult to detect. The main focus of the Duke CHAVI-ID is to desi [..]

 - the Env that was obtained from patient CH505 who developed neutralization breadth during follow-up from acute HIV-1 infection. This person was the first CHAVI 17 participant who was studied for ant [..]