Within the InterPro resources a protein family is defined as distinct functional, structural or sequence units that may exist in a variety of biological contexts. A match to an InterPro entry of this [..]

Secondary databases comprise data derived from the results of analysing primary data. They are often referred to as curated databases but this is a bit of a misnomer as primary databases are also cura [..]

Refers to a sequence of DNA, RNA or amino acids that reflects the most common choice of base or amino acid at each position. To reduce redundancy, the UniProtKB/Swiss-Prot policy is to describe all th [..]

European Genome-phenome Archive. A repository for genotype experiments, including information such as population and family studies. http://www.ebi.ac.uk/ega/page.php

When a sequence alignment is scored, gaps in the alignment caused by insertions or deletions are given a negative score or gap penalty.

A genetic phenomenon that describes the effects of the improved or increased function of any biological quality due to selective breeding to generate offsprings that are genetically superior to their [..]

Methylation is the addition of a methyl group to a substrate or the substitution of an atom, or group, by a methyl group. You can find out more about methylation on the Wikipedia page: http://en.wikip [..]

PSI-BLAST (Position-Specific Iterative Basic Local Alignment Search Tool) derives a position-specific scoring matrix (PSSM) from the multiple sequence alignment of sequences detected above a given sco [..]

PSICQUIC is a project led by the HUPO Proteomics Standard Initiative (HUPO-PSI) that aims to standardise programmatic access to molecular interaction databases. A single query can access multiple data [..]

PubMed is a search engine offering access to the MEDLINE database. A free and searchable repository of scientific citations across multiple journals and books, housed at the NCBI. http://www.ncbi.nlm. [..]