A type of cancer that begins in the cells that line certain internal organs, such as the colon, breasts, lungs, stomach, esophagus, pancreas, ovaries, uterus, and prostate.

Antibodies are proteins that are natulaly found in the blood stream and in other bodily fluids.  Antibodies are used by the immune system to identify and neutralize “foreign objects”, such as bacteria, viruses, and cancer cells. 

Any material that is recognized by the immune system as dissimilar to “organism owned structures”. Antigens can be recognized and bound by an antibody. Tumor antigens can be found on the surface of cancerous cells or can be released into the surrounding tumor cell environment.

Enlyton’s first product for SPECT/CT imaging of cancer. ENL210 is composed of an anti-TAG-72 humanized monoclonal antibody fragment and is coupled to iodine-123 (a radioactive substance).

Computed tomography. Also called CAT scan, computed tomography scan, computerized axial tomography scan, and computerized tomography. A CT scan is series of detailed X-ray type pictures of areas inside the body taken from different angles to produce cross-sectional images of bones and soft tissues. Each CT images is effectively a single “slice” of [..]

Fluorine-18 labeled fluorodeoxyglucose.  18F-FDG is a radioactive material that is frequently used in PET scanning. 18F-FDG is a compound composed of a radioactive fluoride atom (18F) attached to a glucose (sugar) molecule. Once injected into the body, 18F-FDG is attracted to cells that exhibit high levels of sugar processing (such as actively grow [..]

Fluorodeoxyglucose. See the definition of 18F-FDG above.

Human anti-murine/mouse antibody.  A protein produced by the body’s immune system in response to the presence of an antibody derived from a mouse.

HuCC49DeltaCH2 is the complimentary determining region (CDR)-grafted humanized CH2-domain-deleted anti-TAG-72 monoclonal antibody. This third generation CC49 monoclonal antibody targets the tumor associated glycoprotein-72, a shed tumor antigen that is expressed by many adenocarcinomas.  The CH2-domain-deleted structure of HuCC49DeltaCH2 helps this [..]

The ability of any particular substance to elicit an immune response.