Amiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong b [..]

N-Amidino-3,5-diamino-6-chloropyrazinecarboxami de monohydrochloride dihydrate. A non-steroidal compound exerting an effect similar to that of an aldosterone inhibitor, i.e., urinary sodium excretion is enhanced and potassium excretion is reduced; a potassium sparing diuretic. (05 Mar 2000)