A specific protein with a mass of 53 kilodaltons that is produced by a tumor-suppressor gene. Like other tumor-suppressor genes, the p53 gene normally controls cell growth. If p53 is physically lost or functionally inactivated, cells can grow without restraint. Many human tumors have mutations in the gene coding for the p53 protein.

A protein that acts as a "checkpoint" in cells, inducing either growth arrest, DNA repair, or cell death when the cell's DNA is damaged. Most cancer cells have mutations in the p53 prot [..]

(TP53) A multifunctional protein Mr 53 kDa regulating cell cycle arrest, apoptosis, senescence, DNA repair, and changes in cell metabolism. As a cell cycle regulator it recognizes and binds damaged DNA (single-stranded DNA, insertion/deletion mismatches, and free DNA ends) and also acts as a transcription factor activating p21 transcription. p53 al [..]

Definition: A gene that normally inhibits the growth of tumors. This gene is altered in many types of cancer so mutation (alteration) of p53 is believed to be a cause of some cancers. It is a subject [..]

p53 is a tumour suppressor gene that acts to, as the name suggests, stop tumours from developing. It does this by activating a number of proteins that trigger cell death in the damaged cell. This stop [..]

A tumor suppressor gene frequently measured as a marker of malignant diseases.

a protein activated following DNA damage which binds to the DNA and promotes the expression of genes which regulate the cell cycle and initiate apoptosis.

 A particularly notable tumor-suppressor gene that is thought to play a central role in normal cells’ growth regulation. Mutation of the P53 tumor suppressor gene has been shown to occur in up to 40 percent of invasive bladder carcinomas. Some scientists believe that P53 mutation may be a marker of the presence of a dangerous type of tumor which co [..]

Back-up IMU orientation determination

A 53KDa protein the product of a tumour suppressor gene. The loss of this protein due to mutation is a primary event in the formation of many types of cancer (breast, colon, lung, leukaemia, liver). P [..]