An hereditary disorder with mental and physical deterioration leading to death. Although characterized as an "adult-onset" disease, it can affect children as well. Huntington disease describes an autosomal dominant pattern of inheritance with high penetrance (a high proportion of persons with the gene develop the disease). The cha [..]

fatal autosomal dominant neurodegenerative disorder characterized by chorea and progressive dementia; due to a trinucleotide CAG-repeat mutation on chromosome 4

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive Chorea and Dementia in the fourth or fifth decade of Life. Common initial manifestations incl [..]

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations incl [..]

An inherited disease due to a defective gene on the short arm of chromosome 4. It results in loss of motor control and mental deterioration. Symptoms frequently do not appear until after reproductive age, meaning the defective gene may already have been passed on to offspring when symptoms develop.