Loss of normal cell differentiation, a feature characteristic of most malignancies.

Any change in the way that cells are arranged and structured in relation to one another.

loss of differentiation of cells and of their orientation to one another and to their framework and blood vessels.

Loss of a cell's differentiated state, or reversion to a more "primative" cellular phenotype. This usually is seen in association with cancer cells.

In the case of a body cell, a reversion to a more primitive condition. A term used to denote the alteration in cell character which constitutes malignancy.

In the case of a body cell, a reversion to a more primitive condition. A term used to denote the alteration in cell character which constitutes malignancy.

(n) loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor

A characteristic of tumor tissue in which there is a loss of differentiation of cells (dedifferentiation), of their orientation to one another, and to their axial framework and relationship to blood v [..]

Synonyms: anaplastic Definition: (an-ah-PLAY-sha) Adj: anaplastic (an-ah-PLAS-tik) When cells divide (mitosis) rapidly and bear little or no resemblance to normal cells in appearance or function. See [..]

Loss of structural differentiation and useful function of neoplastic Cells.

Loss of structural differentiation and useful function of neoplastic cells.

Lack of differentiated features in a cancer cell, characterized by cellular pleomorphism (variation in size and shape of cells and their nuclei), enlarged and hyperchromatic nuclei, prominant nucleoli, atypical mitoses, and bizarre cells, including giant cells.

The reversion of a cell to a simpler, undifferentiated form.

<pathology, oncology> Characteristics of a cell (structure and orientation) that make it identifiable as a cancer cell and malignant. There is lack of differentiation, which is characteristic of some tumour cells. Origin: Gr. Plassein = to form (16 Dec 1997)